It is possible to take Vidalista 20mg with or without food. It must be taken exactly as prescribed by your physician. Only when you are sexually stimulated will the ED medication help you achieve an erection. It is best to take it before your planned sexual activity Only when you are sexually stimulated can this medication aid in achieving an erection. Although it works wonders, it must be taken at least 30 to 60 minutes before engaging in sexual activity. As directed by your physician, take this medication for the prescribed amount of time. Avoid chewing, crushing, or breaking it. It is preferable to take it at night, however it can be taken with or without food.